If you prefer to direct mode mailing, DNS settings are always important for querying mail exchange information. A DNS shall be a valid IP address like '123.12.11.111'.

Preferred DNS Server
IP address for preferred DNS Server. It is recommended you enter a local DNS
in your local network.
Alternate DNS Server
IP address for secondly DNS Server, it is optional.
Detect
Acquires and fills DNS servers from your network.
Test
Tests if the DNS servers work or not.
Query timeout
Timeout for querying a mail exchange record, the default is 5 seconds.
Query retry
Retry count for querying a mail exchange record, the default is 10 times.
Buffer MX Exchange query results
Queries buffered results in the application instead of always querying the
DNS server. DNS caching speeds up your delivery.
Clear MX Exchange buffer before publish
Clears the buffer before you starting a mailing task.